ES8505972A1 - Un procedimiento para preparar derivados de pirimidina - Google Patents

Un procedimiento para preparar derivados de pirimidina

Info

Publication number
ES8505972A1
ES8505972A1 ES530916A ES530916A ES8505972A1 ES 8505972 A1 ES8505972 A1 ES 8505972A1 ES 530916 A ES530916 A ES 530916A ES 530916 A ES530916 A ES 530916A ES 8505972 A1 ES8505972 A1 ES 8505972A1
Authority
ES
Spain
Prior art keywords
preparation
pyrimidine derivatives
general formula
agent
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530916A
Other languages
English (en)
Spanish (es)
Other versions
ES530916A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838308290A external-priority patent/GB8308290D0/en
Priority claimed from GB838315542A external-priority patent/GB8315542D0/en
Priority claimed from GB838327859A external-priority patent/GB8327859D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES530916A0 publication Critical patent/ES530916A0/es
Publication of ES8505972A1 publication Critical patent/ES8505972A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES530916A 1983-03-25 1984-03-23 Un procedimiento para preparar derivados de pirimidina Expired ES8505972A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB838308290A GB8308290D0 (en) 1983-03-25 1983-03-25 Pyrimidinone derivatives
GB838315542A GB8315542D0 (en) 1983-06-07 1983-06-07 Pyrimidinone derivatives
GB838327859A GB8327859D0 (en) 1983-10-18 1983-10-18 Pyrimidine derivatives

Publications (2)

Publication Number Publication Date
ES530916A0 ES530916A0 (es) 1985-06-16
ES8505972A1 true ES8505972A1 (es) 1985-06-16

Family

ID=27262023

Family Applications (2)

Application Number Title Priority Date Filing Date
ES530916A Expired ES8505972A1 (es) 1983-03-25 1984-03-23 Un procedimiento para preparar derivados de pirimidina
ES538190A Expired ES8601922A1 (es) 1983-03-25 1984-11-30 Un procedimiento para preparar derivados de pirimidina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES538190A Expired ES8601922A1 (es) 1983-03-25 1984-11-30 Un procedimiento para preparar derivados de pirimidina

Country Status (13)

Country Link
US (3) US4612376A (en])
EP (1) EP0123402B1 (en])
KR (1) KR840008333A (en])
CA (1) CA1256107A (en])
DE (1) DE3473875D1 (en])
DK (1) DK160492C (en])
ES (2) ES8505972A1 (en])
FI (1) FI841128A7 (en])
GR (1) GR81758B (en])
HU (1) HU195195B (en])
NO (1) NO841168L (en])
PH (1) PH22022A (en])
SU (2) SU1349698A3 (en])

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
US4649142A (en) * 1984-06-25 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. 3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent
US4708958A (en) * 1986-09-24 1987-11-24 G. D. Searle & Co. 6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents
US5521315A (en) * 1993-01-12 1996-05-28 Cell Therapeutics, Inc. Olefin substituted long chain compounds
IT1270122B (it) * 1994-10-04 1997-04-28 Ist Superiore Sanita 6-benzil-4-ossopirimidine sostituite, processo per la loro preparazione e composizioni farmaceutiche che le contengono
CA2230516C (en) * 1995-09-06 2008-11-18 Kowa Co., Ltd. Pyrimidine derivatives
US6244121B1 (en) * 1998-03-06 2001-06-12 Applied Materials, Inc. Sensor device for non-intrusive diagnosis of a semiconductor processing system
PL377847A1 (pl) 2003-01-14 2006-02-20 Arena Pharmaceuticals Inc. 1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia
MXPA06000554A (es) 2003-07-14 2006-07-03 Arena Pharm Inc Derivados arilo y heteroarilo fusionados como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con los mismos.
DOP2006000009A (es) 2005-01-13 2006-08-15 Arena Pharm Inc Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
NZ565955A (en) 2005-08-22 2011-08-26 Melior Pharmaceuticals I Inc Methods and formulations for modulating lyn kinase activity and treating related disorders
JP2010518860A (ja) * 2007-02-20 2010-06-03 メリオール・ファーマスーティカルズ・ワン・インコーポレイテッド Ｌｙｎキナーゼの活性化剤の同定方法
WO2009015133A1 (en) * 2007-07-23 2009-01-29 Melior Discovery, Inc. Methods of activating irs-1 and akt
US8552184B2 (en) * 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
US8609676B2 (en) * 2009-08-04 2013-12-17 Merck Sharp & Dohme, Corp. 4, 5, 6-trisubstituted pyrimidine derivatives as factor IXa inhibitors
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
PE20131371A1 (es) 2010-09-22 2013-11-25 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con este
WO2016031987A1 (ja) * 2014-08-29 2016-03-03 国立大学法人東京大学 オートタキシン阻害活性を有するピリミジノン誘導体
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity
PT3242666T (pt) 2015-01-06 2024-12-09 Arena Pharm Inc Composto para utilização no tratamento de patologias relacionadas com o recetor s1p1
SI3310760T1 (sl) 2015-06-22 2023-02-28 Arena Pharmaceuticals, Inc. Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
EP3609500B1 (en) 2017-04-10 2024-11-13 Melior Pharmaceuticals I, Inc. Treatment of adipocytes
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
CN109053589A (zh) * 2018-09-30 2018-12-21 浙江师范大学 4-亚胺基四氢嘧啶-2-酮类化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1296371A (en]) * 1969-02-26 1972-11-15
AU1108070A (en) * 1969-03-06 1971-08-12 Imperial Chemical Industries Limited Pyrimidine derivatives
GB1336138A (en) * 1969-12-10 1973-11-07 Ici Ltd Process for the production of pyrimidine derivatives
US3923807A (en) * 1973-09-10 1975-12-02 Takeda Chemical Industries Ltd 6-Aminouracil derivatives
US4208366A (en) * 1978-10-31 1980-06-17 E. I. Du Pont De Nemours And Company Process for preparing a nonwoven web
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent

Also Published As

Publication number Publication date
ES538190A0 (es) 1985-11-01
CA1256107A (en) 1989-06-20
SU1436872A3 (ru) 1988-11-07
DK160492C (da) 1991-08-26
US4746664A (en) 1988-05-24
DK166884D0 (da) 1984-03-23
PH22022A (en) 1988-05-13
DK166884A (da) 1984-09-26
NO841168L (no) 1984-09-26
FI841128A0 (fi) 1984-03-21
DK160492B (da) 1991-03-18
EP0123402A3 (en) 1985-09-18
FI841128A7 (fi) 1984-09-26
SU1349698A3 (ru) 1987-10-30
ES8601922A1 (es) 1985-11-01
GR81758B (en]) 1984-12-12
ES530916A0 (es) 1985-06-16
US4824851A (en) 1989-04-25
EP0123402A2 (en) 1984-10-31
KR840008333A (ko) 1984-12-14
HU195195B (en) 1988-04-28
US4612376A (en) 1986-09-16
EP0123402B1 (en) 1988-09-07
DE3473875D1 (en) 1988-10-13

Similar Documents

Publication Publication Date Title
ES8505972A1 (es) Un procedimiento para preparar derivados de pirimidina
ES8506021A1 (es) Procedimiento para preparar derivados de 4-oxo-1, 4-dihidroquinoleina
DK177585D0 (da) Pyridazinoner
NL7704712A (nl) Werkwijze voor de bereiding van nieuwe aminozuurderivaten.
FI800143A7 (fi) Menetelmä imidatsolijohdannaisten valmistamiseksi.
NO151860C (no) Fremgangsmaate for fremstilling av dinatriumsaltet av 1,3-bis-(2-karboksykromon-5-yloksy)propan-2-ol
IE43531L (en) Benzimidazole derivatives.
IT8022265A0 (it) Derivati di alchil-chetoesopiranosidi.
ES8202015A1 (es) Un procedimiento para la preparacion de derivados de penici-lina
BG33278A3 (en) Method for making of carbamide derivatives
ES8502703A1 (es) Un procedimiento para la preparacion de nuevos derivados de tienopirimidina.
IT8021606A0 (it) Gas di sintesi per la produzione di ammoniaca.
IT7927749A0 (it) Procedimento per la preparazione di urea.
ES480112A1 (es) Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina.
IT1089631B (it) Procedimento per la preparazione di glicoli vicinali
IT7822004A0 (it) Procedimento per la preparazione di guanidina.
SE8700555D0 (sv) Purine derivatives, their production and medicaments containing them
NL7707515A (nl) Werkwijze voor de bereiding van cyanuurzuur- derivaten.
AR218247A1 (es) Procedimiento para la obtencion de derivados de 1-(2-aminoetil)-3-(2,6-dihalofenil)-tiourea
AR226869A1 (es) Procedimiento para la preparacion de derivados de 7-(3-ter.butil-e isopropil-amino-2-hidroxi-propoxi)-1-alquilo(c1-c4)o fenil alquilo(c1-c4)sustituido 2,3-indolediona
ES489184A0 (es) Procedimiento para la produccion de derivados de feobromina.
ES8402839A1 (es) Procedimiento para la obtencion de nuevos poliazaheterociclicos policiclicos.
ES2067780T3 (es) 2'-desoxi-2'-metilidenocitidina dihidrato, metodos para su produccion y composiciones.
IT7822003A0 (it) Veicolo per il trasporto di pezzi.
IT7828659A0 (it) Procedimento per la fabbricazione di nitroguanidina.

Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506